4 papers
Loop Extrusion Reversal by Condensin Motor is Mediated by Catch Bonds
Atreya Dey, Guang Shi, Ryota Takaki +1
Structural Maintenance Complexes (SMC) are energy consuming motors that are important in folding the genome by loop extrusion (LE) in all stages of the cell cycle. Single molecule…
Epigenetic state encodes locus-specific chromatin mechanics
Guang Shi, D. Thirumalai
Chromatin is repeatedly deformed in vivo during transcription, nuclear remodeling, and confined migration - yet how mechanical response varies from locus to locus, and how it relat…
Static Three-Dimensional Structures Determine Fast Dynamics Between Distal Loci Pairs in Interphase Chromosomes
Guang Shi, Sucheol Shin, D. Thirumalai
Live-cell imaging experiments have shown that the distal dynamics between enhancers and promoters are unexpectedly rapid and incompatible with standard polymer models. The discorda…
Organization and Dynamics of Chromosomes
D. Thirumalai, Guang Shi, Sucheol Shin +1
How long threadlike eukaryotic chromosomes fit tidily in the small volume of the nucleus without significant entanglement is just beginning to be understood, thanks to major advanc…