4 papers
Enhancing Cryo-EM Density Map Segmentation in Phenix for Improved Atomic Model Building
Chenwei Zhang
We introduce PhenixCraft, a fully automated pipeline for building atomic models from cryo-EM density maps. By integrating AlphaFold predictions, we enhance the map-segmentation ste…
Applications of deep generative models to DNA reaction kinetics and to cryogenic electron microscopy
Chenwei Zhang
This dissertation explores how deep generative models can advance the analysis of challenging biological problems by integrating domain knowledge with deep learning. It focuses on…
CryoSAMU: Enhancing 3D Cryo-EM Density Maps of Protein Structures at Intermediate Resolution with Structure-Aware Multimodal U-Nets
Chenwei Zhang, Khanh Dao Duc
Enhancing cryogenic electron microscopy (cryo-EM) 3D density maps at intermediate resolution (4-8 Ã ) is crucial in protein structure determination. Recent advances in deep learnin…
Struc2mapGAN: improving synthetic cryo-EM density maps with generative adversarial networks
Chenwei Zhang, Anne Condon, Khanh Dao Duc
Generating synthetic cryogenic electron microscopy 3D density maps from molecular structures has potential important applications in structural biology. Yet existing simulation-bas…