2 papers
stat.ME2026
Two-Stage Design with Sample Size Re-estimation Using gsDesign
Keaven M. Anderson, Alison Pedley
The effect size and nuisance parameters needed to appropriately size a clinical trial are generally not adequately understood before a trial begins. Through pre-planned early stopp…
stat.ME2025
Group Sequential Design for Non-Proportional Hazards: Logrank, Weighted Logrank, and MaxCombo Methods
Yujie Zhao, Yilong Zhang, Larry Leon +1
Non-proportional hazards (NPH) are often observed in clinical trials with time-to-event endpoints. A common example is a long-term clinical trial with a delayed treatment effect in…