5 papers · 1 filter
Estimation of treatment effects in presence of differential use of post-randomization concomitant medication with time-to-event outcomes
Helene C. W. Rytgaard, Edwin Fong, Jens M. Tarp +3
In placebo-controlled randomized trials, the post-randomization use of concomitant medications may be higher in the placebo arm than in the treatment arm. This may dilute the full…
Causal inference for calibrated scaling interventions on time-to-event processes
Helene Charlotte Wiese Rytgaard, Mark van der Laan
This work develops a flexible inferential framework for nonparametric causal inference in time-to-event settings, based on stochastic interventions defined through multiplicative s…
Proximal indirect comparison
Zehao Su, Helene C. W. Rytgaard, Henrik Ravn +1
We consider the problem of indirect comparison, where a treatment arm of interest is absent by design in one randomized controlled trial but available in the other. The former is t…
Efficient estimation of the target population average treatment effect from multi-source data
Zehao Su, Helene Charlotte Rytgaard, Henrik Ravn +1
We consider estimation of the target population average treatment effect (TATE) when outcome information is unavailable. Instead, we observe the outcome in multiple source populati…
Nonparametric efficient causal estimation of the intervention-specific expected number of recurrent events with continuous-time targeted maximum likelihood and highly adaptive lasso estimation
Helene C. W. Rytgaard, Mark J. van der Laan
Longitudinal settings involving outcome, competing risks and censoring events occurring and recurring in continuous time are common in medical research, but are often analyzed with…