3 papers
stat.ME2026
Unbiased estimation in two-stage adaptive enrichment designs
Enyu Li, Nigel Stallard, Ekkehard Glimm +1
Recent advances in biomedical research have identified an increasing number of biomarkers associated with heterogeneity in patient responses to medical treatments. When a treatment…
stat.ME2026
Confidence intervals for two-stage adaptive designs with subpopulation selection
Enyu Li, Nigel Stallard, Ekkehard Glimm +2
We consider clinical trials in which an experimental treatment is compared with a control in pre-specified patient subpopulations. In such settings, adaptive enrichment designs all…
stat.ME2025
Exact matching as an alternative to propensity score matching
Ekkehard Glimm, Lillian Yau
The comparison of different medical treatments from observational studies or across different clinical studies is often biased by confounding factors such as systematic differences…