125 citations · 151 across the 4 of their papers we have counts for
5 papers
Spontaneous Lipid Binding to the Nicotinic Acetylcholine Receptor in a Native Membrane
Liam Sharp, Grace Brannigan
The nicotinic acetylcholine receptor (nAChR) and other pentameric ligand-gated ion channels (pLGICs) are native to neuronal membranes with an unusual lipid composition. While it is…
Untangling direct and domain-mediated interactions between nicotinic acetylcholine receptors in DHA-rich membranes
Kristen Woods, Liam Sharp, Grace Brannigan
At the neuromuscular junction (NMJ), the nicotinic acetylcholine receptor (nAChR) self-associates to give rise to rapid muscle movement. While lipid domains have maintained nAChR a…
Boundary lipids of the nicotinic acetylcholine receptor: spontaneous partitioning via coarse-grained molecular dynamics simulation
Liam Sharp, Reza Salari, Grace Brannigan
Reconstituted nicotinic acetylcholine receptors (nAChRs) exhibit significant gain-of-function upon addition of cholesterol to reconstitution mixtures, and cholesterol affects organ…
A streamlined, general approach for computing ligand binding free energies and its application to GPCR-bound cholesterol
Reza Salari, Thomas Joseph, Ruchi Lohia +2
The theory of receptor-ligand binding equilibria has long been well-established in biochemistry, and was primarily constructed to describe dilute aqueous solutions. Accordingly, fe…
Flexible Lipid Bilayers in Implicit Solvent
Grace Brannigan, Peter F. Philips, Frank L. H. Brown
A minimalist simulation model for lipid bilayers is presented. Each lipid is represented by a flexible chain of beads in implicit solvent. The hydrophobic effect is mimicked throug…