5 citations · 6 across the 5 of their papers we have counts for
11 papers
3D hybrid cellular Potts model with a discrete deformable fiber network: modeling cell contraction and extracellular matrix remodeling
Koen A. E. Keijzer, Roeland M. H. Merks
The extracellular matrix (ECM) is a fibrous and dynamic network that plays a critical role in development, homeostasis, and disease. Cells both respond to and remodel the ECM, enga…
Deformability and collision-induced reorientation enhance cell topotaxis in dense microenvironments
Leonie van Steijn, Joeri A. J. Wondergem, Koen Schakenraad +2
In vivo, cells navigate through complex environments filled with obstacles. Recently, the term 'topotaxis' has been introduced for navigation along topographic cues such as obstacl…
Scaling Relations for Auxin Waves
Timothy E. Faver, Hermen Jan Hupkes, Roeland M. H. Merks +1
We analyze an 'up-the-gradient' model for the formation of transport channels of the phytohormone auxin, through auxin-mediated polarization of the PIN1 auxin transporter. We show…
Chiral stresses in nematic cell monolayers
Ludwig A. Hoffmann, Koen Schakenraad, Roeland M. H. Merks +1
Recent experiments on monolayers of spindle-like cells plated on adhesive stripe-shaped domains have provided a convincing demonstration that certain types of collective phenomena…
Topotaxis of active Brownian particles
Koen Schakenraad, Linda Ravazzano, Niladri Sarkar +3
Recent experimental studies have demonstrated that cellular motion can be directed by topographical gradients, such as those resulting from spatial variations in the features of a…
Cell Shape and Durotaxis Follow from Mechanical Cell-Substrate Reciprocity and Focal Adhesion Dynamics: A Unifying Mathematical Model
Elisabeth G. Rens, Roeland M. H. Merks
Many animal cells change their shape depending on the stiffness of the substrate on which they are cultured: they assume small, rounded shapes in soft ECMs, they elongate within st…