4 papers
Incorporating Missing Data Considerations into Sample Size Calculations for Developing Clinical Prediction Models
Glen P. Martin, Sian Bladon, Rebecca Whittle +3
Clinical prediction models must be developed using sufficiently large datasets to minimise overfitting and ensure robust predictive performance. Existing sample size calculations a…
A general sample size framework for developing or updating a clinical prediction model
Richard D Riley, Rebecca Whittle, Mohsen Sadatsafavi +4
Aims: To propose a general sample size framework for developing or updating a clinical prediction model using any statistical or machine learning method, based on drawing samples f…
A decomposition of Fisher's information to inform sample size for developing fair and precise clinical prediction models -- Part 2: time-to-event outcomes
Richard D Riley, Gary S Collins, Lucinda Archer +9
Background: When developing a clinical prediction model using time-to-event data, previous research focuses on the sample size to minimise overfitting and precisely estimate the ov…
A decomposition of Fisher's information to inform sample size for developing fair and precise clinical prediction models -- part 1: binary outcomes
Richard D Riley, Gary S Collins, Rebecca Whittle +11
When developing a clinical prediction model, the sample size of the development dataset is a key consideration. Small sample sizes lead to greater concerns of overfitting, instabil…