3 papers
q-bio.PE2026
Optimization of sequential therapies to maximize extinction of resistant bacteria through collateral sensitivity
Javier Molina-Hernández, José A. Cuesta, Beatriz Pascual-Escudero +2
Antimicrobial resistance (AMR) threatens global health. A promising and underexplored strategy to tackle this problem is sequential therapies exploiting collateral sensitivity (CS)…
q-bio.PE2026
Microbiome association diversity reflects proximity to the edge of instability
Rubén Calvo, Adrián Roig, Roberto Corral López +3
Recent advances in metagenomics have revealed macroecological patterns or "laws" describing robust statistical regularities across microbial communities. Stochastic logistic models…
q-bio.PE2026
The challenge of scale in molecular adaptation: Local searches in astronomical genotype networks
Susanna Manrubia, Luis F. Seoane, José A. Cuesta
The exploration of vast genotype spaces poses fundamental challenges for evolving populations. As the number of genotypes encoding viable phenotypes grows exponentially with genome…