2 papers
cs.LG2024
Multi-level Interaction Modeling for Protein Mutational Effect Prediction
Yuanle Mo, Xin Hong, Bowen Gao +2
Protein-protein interactions are central mediators in many biological processes. Accurately predicting the effects of mutations on interactions is crucial for guiding the modulatio…
cs.LG2023
ProFSA: Self-supervised Pocket Pretraining via Protein Fragment-Surroundings Alignment
Bowen Gao, Yinjun Jia, Yuanle Mo +4
Pocket representations play a vital role in various biomedical applications, such as druggability estimation, ligand affinity prediction, and de novo drug design. While existing ge…