3 papers
cs.LG2024
DEFT: Efficient Fine-Tuning of Diffusion Models by Learning the Generalised -transform
Alexander Denker, Francisco Vargas, Shreyas Padhy +7
Generative modelling paradigms based on denoising diffusion processes have emerged as a leading candidate for conditional sampling in inverse problems. In many real-world applicati…
q-bio.QM2024
Improved motif-scaffolding with SE(3) flow matching
Jason Yim, Andrew Campbell, Emile Mathieu +9
Protein design often begins with the knowledge of a desired function from a motif which motif-scaffolding aims to construct a functional protein around. Recently, generative models…
cs.LG2023
A framework for conditional diffusion modelling with applications in motif scaffolding for protein design
Kieran Didi, Francisco Vargas, Simon V Mathis +4
Many protein design applications, such as binder or enzyme design, require scaffolding a structural motif with high precision. Generative modelling paradigms based on denoising dif…