2 papers
q-bio.CB2024
The development of drug resistance in metastatic tumours under chemotherapy: an evolutionary perspective
Federica Padovano, Chiara Villa
We present a mathematical model of the evolutionary dynamics of a metastatic tumour under chemotherapy, comprising non-local partial differential equations for the phenotype-struct…
q-bio.PE2024
Reducing phenotype-structured PDE models of cancer evolution to systems of ODEs: a generalised moment dynamics approach
Chiara Villa, Philip K Maini, Alexander P Browning +3
Intratumour phenotypic heterogeneity is nowadays understood to play a critical role in disease progression and treatment failure. Accordingly, there has been increasing interest in…