3 papers
q-bio.BM2005
Solvent and mutation effects on the nucleation of amyloid -protein folding
Luis Cruz, Brigita Urbanc, Jose M. Borreguero +3
Experimental evidence suggests that the folding and aggregation of the amyloid -protein (A) into oligomers is a key pathogenetic event in Alzheimer's disease (AD). Inhibiting…
physics.bio-ph2003
Multiple Folding Pathways of the SH3 domain
J. M. Borreguero, F. Ding, S. V. Buldyrev +2
Experimental observations suggest that proteins follow different pathways under different environmental conditions. We perform molecular dynamics simulations of a model of the SH3…
cond-mat.soft2002
A possible mechanism for cold denaturation of proteins at high pressure
Manuel I. Marques, Jose M. Borreguero, H. Eugene Stanley +1
We study cold denaturation of proteins at high pressures. Using multicanonical Monte Carlo simulations of a model protein in a water bath, we investigate the effect of water densit…