22 citations · 28 across the 5 of their papers we have counts for
6 papers
Discovery of novel antimicrobial peptides with notable antibacterial potency by a LLM-based foundation model
Jike Wang, Jianwen Feng, Yu Kang +16
Large language models (LLMs) have shown remarkable advancements in chemistry and biomedical research, acting as versatile foundation models for various tasks. We introduce AMP-Desi…
AAVDiff: Experimental Validation of Enhanced Viability and Diversity in Recombinant Adeno-Associated Virus (AAV) Capsids through Diffusion Generation
Lijun Liu, Jiali Yang, Jianfei Song +8
Recombinant adeno-associated virus (rAAV) vectors have revolutionized gene therapy, but their broad tropism and suboptimal transduction efficiency limit their clinical applications…
Deep Geometry Handling and Fragment-wise Molecular 3D Graph Generation
Odin Zhang, Yufei Huang, Shichen Cheng +14
Most earlier 3D structure-based molecular generation approaches follow an atom-wise paradigm, incrementally adding atoms to a partially built molecular fragment within protein pock…
Generative AI for Controllable Protein Sequence Design: A Survey
Yiheng Zhu, Zitai Kong, Jialu Wu +6
The design of novel protein sequences with targeted functionalities underpins a central theme in protein engineering, impacting diverse fields such as drug discovery and enzymatic…
Multiscale Topology in Interactomic Network: From Transcriptome to Antiaddiction Drug Repurposing
Hongyan Du, Guo-Wei Wei, Tingjun Hou
The escalating drug addiction crisis in the United States underscores the urgent need for innovative therapeutic strategies. This study embarked on an innovative and rigorous strat…
Multi-channel learning for integrating structural hierarchies into context-dependent molecular representation
Yue Wan, Jialu Wu, Tingjun Hou +2
Reliable molecular property prediction is essential for various scientific endeavors and industrial applications, such as drug discovery. However, the data scarcity, combined with…