2 papers
q-bio.QM2024
Quantifying "just-right" APC inactivation for colorectal cancer initiation
Meritxell Brunet Guasch, Nathalie Feeley, Ignacio Soriano +4
Dysregulation of the tumour suppressor gene Adenomatous Polyposis Coli (APC) is a canonical step in colorectal cancer development. Curiously, most colorectal tumours carry bialleli…
q-bio.PE2023
Error-induced extinction in a multi-type critical birth-death process
Meritxell Brunet Guasch, P. L. Krapivsky, Tibor Antal
Extreme mutation rates in microbes and cancer cells can result in error-induced extinction (EEX), where every descendant cell eventually acquires a lethal mutation. In this work, w…