2 papers
math.OC2026
Identifying Multi-Hit Cancer Drivers Without Massive Parallelization: A CP, MIP, and Column Generation Framework
Rick S. H. Willemsen, Tenindra Abeywickrama, Ramu Anandakrishnan
Cancer is often driven by specific combinations of an estimated two to nine gene mutations, known as multi-hit combinations. Identifying these multi-hit combinations of gene mutati…
math.OC2025
Generating Random Vectors satisfying Linear and Nonlinear Constraints
Rick S. H. Willemsen, Wilco van den Heuvel, Michel van de Velden
We consider the problem of generating n-dimensional vectors with a fixed sum, with the goal of generating a uniform distribution of vectors over a valid region. This means that eac…