Conformational Dynamics of 8-Oxoguanine Mispairing Reveal a Mechanism of Polymerase λ Misincorporation

George Ferguson, Louie Slocombe, Max Winokan +2

Experimental evidence has shown the stability of oxygen-stress-damaged guanine, known as 8-oxoguanine. This common oxygen-damaged nucleobase is often found in the presence of react…