6 citations · 6 across the 4 of their papers we have counts for
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stat.AP2025
SIMBA -- A Bayesian Decision Framework for the Identification of Optimal Biomarker Subgroups for Cancer Basket Clinical Trials
Shijie Yuan, Jiaxin Liu, Zhihua Gong +4
We consider basket trials in which a biomarker-targeting drug may be efficacious for patients across different disease indications. Patients are enrolled if their cells exhibit som…
stat.AP2024
The Modified Combo i3+3 Design for Novel-Novel Combination Dose-Finding Trials in Oncology
Jiaxin Liu, Shijie Yuan, Qiqi Deng +1
We consider a modified Ci3+3 (MCi3+3) design for dual-agent dose-finding trials in which both agents are tested on multiple doses. This usually happens when the agents are novel th…
stat.AP2023★ 6 cited
Pharmacometrics-Enabled DOse OPtimization (PEDOOP) for Seamless Phase I-II Trials in Oncology
Shijie Yuan, Zhanbo Huang, Jiaxin Liu +1
We consider a dose-optimization design for first-in-human oncology trial that aims to identify a suitable dose for late-phase drug development. The proposed approach, called the Ph…