4 papers
Bistability, Absolute Concentration Robustness, and Hysteresis in Dual-Site Futile Cycles with Bifunctional Enzymes
Badal Joshi, Tung D. Nguyen, Matthew D. Johnston
Bifunctional enzymes, which catalyze both the forward and reverse steps of a substrate modification reaction, arise naturally in bacterial two-component signaling systems and metab…
Computing with reaction networks at input-independent speed: exponential and logarithmic functions
David F. Anderson, Badal Joshi, Tung D. Nguyen
The concept of input-independent computational time for chemistry-based analog computers was introduced in Anderson-Joshi (2025), where it was shown that arithmetic operations can…
Bifunctional enzyme action as a source of robustness in biochemical reaction networks: a novel hypergraph approach
Badal Joshi, Tung D. Nguyen
Substrate modification networks are ubiquitous in living, biochemical systems. A higher-level hypergraph "skeleton" captures key information about which substrates are transformed…
Chemical mass-action systems as analog computers: implementing arithmetic computations at specified speed
David F. Anderson, Badal Joshi
Recent technological advances allow us to view chemical mass-action systems as analog computers. In this context, the inputs to a computation are encoded as initial values of certa…