5 papers
Probing RLVR training instability through the lens of objective-level hacking
Yiming Dong, Kun Fu, Haoyu Li +5
Prolonged reinforcement learning with verifiable rewards (RLVR) has been shown to drive continuous improvements in the reasoning capabilities of large language models, but the trai…
GENERator: A Long-Context Generative Genomic Foundation Model
Wei Wu, Qiuyi Li, Yuanyuan Zhang +15
The rapid advancement of DNA sequencing has produced vast genomic datasets, yet interpreting and engineering genomic function remain fundamental challenges. Recent large language m…
Structure-Enhanced Protein Instruction Tuning: Towards General-Purpose Protein Understanding with LLMs
Wei Wu, Chao Wang, Liyi Chen +6
Proteins, as essential biomolecules, play a central role in biological processes, including metabolic reactions and DNA replication. Accurate prediction of their properties and fun…
A Generalist Cross-Domain Molecular Learning Framework for Structure-Based Drug Discovery
Yiheng Zhu, Mingyang Li, Junlong Liu +7
Structure-based drug discovery (SBDD) is a systematic scientific process that develops new drugs by leveraging the detailed physical structure of the target protein. Recent advance…
Bridge-IF: Learning Inverse Protein Folding with Markov Bridges
Yiheng Zhu, Jialu Wu, Qiuyi Li +7
Inverse protein folding is a fundamental task in computational protein design, which aims to design protein sequences that fold into the desired backbone structures. While the deve…