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Excess of genomic defects in a woolly mammoth on Wrangel island
Rebekah L. Rogers, Montgomery Slatkin
Woolly mammoths (Mammuthus primigenius) populated Siberia, Beringia, and North America during the Pleistocene and early Holocene. Recent breakthroughs in ancient DNA sequencing hav…
Bayesian inference of natural selection from allele frequency time series
Joshua G. Schraiber, Steven N. Evans, Montgomery Slatkin
The advent of accessible ancient DNA technology now allows the direct ascertainment of allele frequencies in ancestral populations, thereby enabling the use of allele frequency tim…
Ancient human genomes suggest three ancestral populations for present-day Europeans
Iosif Lazaridis, Nick Patterson, Alissa Mittnik +117
We sequenced genomes from a 7,000 year old early farmer from Stuttgart in Germany, an 8,000 year old hunter-gatherer from Luxembourg, and seven 8,000 year old hun…
Detecting range expansions from genetic data
Benjamin M Peter, Montgomery Slatkin
We propose a method that uses genetic data to test for the occurrence of a recent range expansion and to infer the location of the origin of the expansion. We introduce a statistic…
Genomic tests of variation in inbreeding among individuals and among chromosomes
Joshua G. Schraiber, Stephannie Shih, Montgomery Slatkin
We examine the distribution of heterozygous sites in nine European and nine Yoruban individuals whose genomic sequences were made publicly available by Complete Genomics. We show t…
Non-equilibrium theory of the allele frequency spectrum
Steven N. Evans, Yelena Shvets, Montgomery Slatkin
A forward diffusion equation describing the evolution of the allele frequency spectrum is presented. The influx of mutations is accounted for by imposing a suitable boundary condit…