2 papers
physics.med-ph2026
Topological structure of radiation-induced DNA damage encodes coupled LET-oxygen signatures
Renato III Fernan Bolo, Ramon Jose C. Bagunu
We present the first nuclear-scale persistent homology and Random Forest classification analysis of radiation-induced DNA double-strand break (DSB) topology across the clinical par…
physics.med-ph2026
Voxel-aware oxygen kinetics resolves radiation-induced DNA damage retention across LET-oxygen conditions
Renato III Fernan Bolo, Ramon Jose C. Bagunu
Objective. Hypoxic tumor subvolumes resist radiation through elevated oxygen enhancement ratios (OER), yet no computational OER model is simultaneously particle-specific, mechanist…