17 citations · 30 across the 6 of their papers we have counts for
6 papers
Learning dynamical systems with biochemically informed neural ordinary differential equations
Luis L. Fonseca, Reinhard C. Laubenbacher, Lucas Böttcher
Ordinary differential equation models of biochemical reactions are often formulated as stoichiometric systems in which the dynamics arise from a collection of interacting processes…
Efficient Portfolio Selection through Preference Aggregation with Quicksort and the Bradley--Terry Model
Yurun Ge, Lucas Böttcher, Tom Chou +1
How to allocate limited resources to projects that will yield the greatest long-term benefits is a problem that often arises in decision-making under uncertainty. For example, orga…
Reconstructing Noisy Gene Regulation Dynamics Using Extrinsic-Noise-Driven Neural Stochastic Differential Equations
Jiancheng Zhang, Xiangting Li, Xiaolu Guo +6
Proper regulation of cell signaling and gene expression is crucial for maintaining cellular function, development, and adaptation to environmental changes. Reaction dynamics in cel…
Surrogate Modeling and Control of Medical Digital Twins
Luis L. Fonseca, Lucas Böttcher, Borna Mehrad +1
The vision of personalized medicine is to identify interventions that maintain or restore a person's health based on their individual biology. Medical digital twins, computational…
Forecasting drug overdose mortality by age in the United States at the national and county levels
Lucas Böttcher, Tom Chou, Maria R. D'Orsogna
The drug overdose crisis in the United States continues to intensify. Fatalities have increased five-fold since 1999 reaching a record high of 108,000 deaths in 2021. The epidemic…
Modeling and forecasting age-specific drug overdose mortality in the United States
Lucas Böttcher, Tom Chou, Maria R. D'Orsogna
Drug overdose deaths continue to increase in the United States for all major drug categories. Over the past two decades the total number of overdose fatalities has increased more t…