4 papers
Fast Generalization after Interpolation via Critically Damped Momentum Optimization
Luca Muscarnera, Silas Ruhrberg Estévez, Yuanzhang Xiao +1
A central problem in machine learning is that models can achieve near-perfect training performance while generalizing substantially less well to unseen examples. This gap is especi…
CellBRIDGE: Learning Cellular Trajectories via Interaction-Aware Alignment
Silas Ruhrberg Estévez, Nicolas Huynh, Tennison Liu +4
Inferring dynamics from population snapshots is a fundamental challenge in machine learning and biology. In scRNA-sequencing (scRNA-seq), destructive measurements preclude direct t…
Knowledge-Informed Kernel State Reconstruction from Heterogeneous Partial Observations
Luca Muscarnera, Silas Ruhrberg Estévez, Samuel Holt +2
Real-world scientific systems are rarely observed through complete, regularly sampled state trajectories. Instead, measurements are often partial, noisy, and heterogeneous, providi…
Automatic Construction of Clinical Scoring Systems with LLM Agents
Silas Ruhrberg Estévez, Christopher Chiu, Mihaela van der Schaar
Modern clinical practice relies on evidence-based guidelines implemented as compact scoring systems composed of a small number of interpretable decision rules. While machine-learni…