2 papers
q-bio.QM2026
SurfSpec: Enhancing Off-Target-Agnostic Specificity by Bounding Pocket-Ligand Geometric Mismatch
Minyeong Hwang, Yoorim Gang, Ziseok Lee +5
Lead optimization in structure-based drug design aims to improve target binding while avoiding unintended interactions with off-target pockets. However, existing affinity-driven me…
cs.CV2026
One Click per Cell Type Suffices: Training-free Group Interaction for Cell Instance Segmentation
Sanghyun Jo, Seo Jin Lee, Seohyung Hong +4
Cell instance segmentation models trained on cell-specific datasets suffer severe performance drops on out-of-distribution cell types, while interactive foundation models overcome…