8 citations · 8 across the 2 of their papers we have counts for
2 papers
q-bio.QM2026
On the interpretation of the kinetics of ligand-receptor binding
David Colquhoun, James P Higham
When the rates of ligand binding are measured by methods such as surface plasmon resonance, it is common practice to use the observed rate constants for the onset and offset of bin…
q-bio.OT2024★ 8 cited
The affinity-efficacy problem: an essential part of pharmacology education
James P Higham, David Colquhoun
A fundamental mistake in receptor theory has led to an enduring misunderstanding of how to estimate the affinity and efficacy of an agonist. These properties are inextricably linke…