Ab initio simulations of Cu binding sites in the N-terminal region of PrP

S. Furlan, G. La Penna, F. Guerrieri +2

The prion protein (PrP) binds Cu2+ ions in the octarepeat domain of the N-terminal tail up to full occupancy at pH=7.4. Recent experiments show that the HGGG octarepeat subdomain i…