8 papers
Conditioning as a route to stereotyped behavior in growing populations
Riccardo Ravasio, Kabir Husain, Constantine G. Evans +4
Biological systems perform complex multi-step processes in a reproducible way despite underlying stochasticity. The standard explanation is micromanagement by molecular machinery t…
The fitness landscape of overlapping genes
Orson Kirsch, Nicole Wood, Steven A Redford +1
Natural genomes sometimes encode two different proteins in staggered reading frames of the same DNA sequence. Despite the prevalence of these 'overlapping genes' across the tree of…
Nonequilibrium protein complexes as molecular automata
Jan Kocka, Kabir Husain, Jaime Agudo-Canalejo
Biology stores information and computes at the molecular scale, yet the ways in which it does so are often distinct from human-engineered computers. Mapping biological computation…
Unifying Theories in High-Dimensional Biology: Approaches, Challenges and Opportunities
Marianne Bauer, Akshit Goyal, Sidhartha Goyal +19
Across biological subdisciplines, the last decade has seen an explosion of high-dimensional datasets, including datasets for cells, species, immune systems, neurons and behaviour.…
Suppression of errors in collectively coded information
Martin J. Falk, Leon Zhou, Yoshiya J. Matsubara +3
Modern life largely transmits genetic information from mother to daughter through the duplication of single physically intact molecules that encode information. However, copying an…
Simple biological controllers drive the evolution of soft modes
Christopher Joel Russo, Kabir Husain, Rama Ranganathan +2
Biological systems, with many interacting components, face high-dimensional environmental fluctuations, ranging from diverse nutrient deprivations to toxins, drugs, and physical st…