5 papers
Dual Ascent Diffusion for Inverse Problems
Minseo Kim, Axel Levy, Gordon Wetzstein
Ill-posed inverse problems are fundamental in many domains, ranging from astrophysics to medical imaging. Emerging diffusion models provide a powerful prior for solving these probl…
Modeling Atomic Conformational Ensembles of Proteins via Test-Time Supervision of Boltz-2 on Cryo-EM Density Maps
Jay Shenoy, Miro Astore, Axel Levy +3
Knowledge of a protein's atomic conformational ensemble is critical to determining its function, yet state-of-the-art ensemble prediction models are limited by lack of high-quality…
Multiscale guidance of protein structure prediction with heterogeneous cryo-EM data
Rishwanth Raghu, Axel Levy, Gordon Wetzstein +1
Protein structure prediction models are now capable of generating accurate 3D structural hypotheses from sequence alone. However, they routinely fail to capture the conformational…
Solving Inverse Problems in Protein Space Using Diffusion-Based Priors
Axel Levy, Eric R. Chan, Sara Fridovich-Keil +3
The interaction of a protein with its environment can be understood and controlled via its 3D structure. Experimental methods for protein structure determination, such as X-ray cry…
Mixture of neural fields for heterogeneous reconstruction in cryo-EM
Axel Levy, Rishwanth Raghu, David Shustin +5
Cryo-electron microscopy (cryo-EM) is an experimental technique for protein structure determination that images an ensemble of macromolecules in near-physiological contexts. While…