52 citations · 52 across the 4 of their papers we have counts for
4 papers
Formation of BCR Oligomers Provides a Mechanism for B cell Affinity Discrimination
Philippos K. Tsourkas, Somkanya C. Das, Paul Yu-Yang +3
B cells encounter antigen over a wide affinity range. The strength of B cell signaling in response to antigen increases with affinity, a process known as "affinity discrimination".…
Discrimination of Membrane Antigen Affinity by B cells Requires Dominance of Kinetic Proofreading over Serial Triggering
Philippos K. Tsourkas, Wanli Liu, Somkanya C Das +2
B cells receptor (BCR) signaling in response to membrane-bound antigen increases with antigen affinity, a process known as affinity discrimination. We use computational modeling to…
Affinity Discrimination in B cells in Response to Membrane Antigen Requires Kinetic Proofreading
Philippos K. Tsourkas, Subhadip Raychaudhuri
B cells signaling in response to antigen is proportional to antigen affinity, a process known as affinity discrimination. Recent research suggests that B cells can acquire antigen…
Mechanisms of B cell Synapse Formation Predicted by Stochastic Simulation
Philippos K. Tsourkas, Nicole Baumgarth, Scott I. Simon +1
The clustering of B cell receptor (BCR) molecules and the formation of the protein segregation structure known as the immunological synapse appears to precede antigen (Ag) uptake b…