4 papers
A Causal Inference Approach for Evaluating Diagnostic Tests and AI-Enabled Medical Devices: From Effect Modification to Information-Augmented Decision-Making
Wenxin Zhang, Rachael Phillips, Mark van der Laan
Diagnostic medical tests and devices provide useful information for evaluating the potential benefits and risks of therapeutic treatments. However, unlike treatments, their impact…
Improving the Efficiency of Subgroup Analysis in Randomized Controlled Trials with TMLE
Sky Qiu, Nerissa Nance, Rachael Phillips +3
Subgroup analyses within randomized controlled trials are often underpowered due to limited sample sizes. We address this challenge by leveraging trial participants outside the sub…
Clinical Reasoning AI for Oncology Treatment Planning: A Multi-Specialty Case-Based Evaluation
Philippe E. Spiess, Md Muntasir Zitu, Alison Walker +33
Background: More than 80% of U.S. cancer care is delivered in community settings, where survival remains worse than at academic centers. Clinicians must integrate genomics, staging…
Hazard-Based Targeted Maximum Likelihood Estimation for Survival in Resampling Designs
Kirsten E. Landsiedel, Rachael V. Phillips, Maya L. Petersen +1
Survival is a key metric for evaluating standards of care for people living with HIV. In resource-limited settings, high rates of loss to follow-up (LTFU) often result in underesti…