159 citations · 177 across the 4 of their papers we have counts for
4 papers
Friends in need: how chaperonins recognize and remodel proteins that require folding assistance
George Stan, George H. Lorimer, D. Thirumalai
Chaperonins are biological nanomachines that help newly translated proteins to fold by rescuing them from kinetically trapped misfolded states. Protein folding assistance by the ch…
Iterative Annealing Mechanism Explains the Functions of the GroEL and RNA Chaperones
D. Thirumalai, George H. Lorimer, Changbong Hyeon
Molecular chaperones are ATP-consuming biological machines, which facilitate the folding of proteins and RNA molecules that are kinetically trapped in misfolded states for long tim…
Symmetry, Rigidity, and Allosteric Signaling: From Monomeric Proteins to Molecular Machines
D. Thirumalai, Changbong Hyeon, Pavel I. Zhuravlev +1
Allosteric signaling in biological molecules, which may be viewed as specific action at a distance due to localized perturbation upon binding of ligands or changes in environmental…
Dynamics of allosteric transitions in GroEL
Changbong Hyeon, George H. Lorimer, D. Thirumalai
The chaperonin GroEL-GroES, a machine which helps some proteins to fold, cycles through a number of allosteric states, the state, with high affinity for substrate proteins (SPs…