76 citations · 260 across the 12 of their papers we have counts for
15 papers
Versatile Femtosecond Laser Synchronization for Multiple-Timescale Transient IR Spectroscopy
Jan Helbing, Peter Hamm
Several ways to electronically synchronize different types of amplified femtosecond laser systems are presented, based on a single freely programmable electronics hardware: Arbitra…
Transient 2D IR spectroscopy and multiscale simulations reveal vibrational couplings in the Cyanobacteriochrome Slr1393-g3
David Buhrke, Yigal Lahav, Aditya Rao +3
Cyanobacteriochromes are bi-stable photoreceptor proteins with desirable photochemical properties for biotechnological applications such as optogenetics or fluorescence microscopy.…
MCL-1 promiscuity and the structural resilience of its binding partners
Philipp J. Heckmeier, Jeannette Ruf, Brankica G. Janković +1
MCL-1 and its natural inhibitors, the BH3-only proteins PUMA, BIM, and NOXA regulate apoptosis by interacting promiscuously within an entangled binding network. Little is known abo…
Structure, Organization and Heterogeneity of Water-Containing Deep Eutectic Solvents
Kai Töpfer, Andrea Pasti, Anuradha Das +6
The spectroscopy and structural dynamics of a deep eutectic mixture (KSCN/acetamide) with varying water content is investigated from 2D IR (with the C-N stretch vibration of the SC…
Hydration Dynamics and IR Spectroscopy of 4-Fluorophenol
Seyedeh Maryam Salehi, Silvan Käser, Kai Töpfer +5
Halogenated groups are relevant in pharmaceutical applications and potentially useful spectroscopic probes for infrared spectroscopy. In this work, the structural dynamics and infr…
Using Azobenzene Photocontrol to Set Proteins in Motion
Olga Bozovic, Brankica Jankovic, Peter Hamm
Controlling the activity of proteins with azobenzene photoswitches is a potent tool for manipulating their biological function. With the help of light, one can change e.g. binding…
The Speed of Allosteric Signaling Within a Single-Domain Protein
Olga Bozovic, Jeannette Ruf, Claudio Zanobini +4
While much is known about different allosteric regulation mechanisms, the nature of the "allosteric signal", and the timescale on which it propagates, remains elusive. The PDZ3 dom…
Sequence of Events During Peptide Unbinding from RNase S: A Complete Experimental Description
Brankica Jankovic, Jeannette Ruf, Claudio Zanobini +3
The photo-triggered unbinding of the intrinsically disordered S-peptide from the RNase S complex is studied with the help of transient IR spectroscopy, covering a wide range of tim…
Intrinsic Dynamics of Protein-Peptide Unbinding
Brankica Jankovic, Olga Bozovic, Peter Hamm
The dynamics of peptide-protein binding and unbinding of a variant of the RNase S system has been investigated. To initiate the process, a photoswitchable azobenzene moiety has bee…
2D Raman-THz spectroscopy of binary CHBr3-MeOH solvent mixture
A. Shalit, S. J. Mousavi, P. Hamm
Hybrid two-dimensional (2D) Raman-terahertz spectroscopy is used to measure the interactions between two solvents pair in the binary CHBr3-MeOH mixture in the frequency range of 1-…
Nanosecond protein dynamics in a red/green Cyanobacteriochrome revealed by transient IR spectroscopy
David Buhrke, Kerstin T. Oppelt, Philipp J. Heckmeier +2
Over the last decades, photoreceptive proteins were extensively studied with biophysical methods to gain a fundamental understanding of their working mechanisms and further guide t…
Real-time observation of ligand-induced allosteric transitions in a PDZ domain
Olga Bozovic, Claudio Zanobini, Adnan Gulzar +6
While allostery is of paramount importance for protein regulation, the underlying dynamical process of ligand (un)binding at one site, resulting time evolution of the protein struc…
Feynman Diagram Description of 2D-Raman-THz Spectroscopy Applied to Water
David Sidler, Peter Hamm
2D-Raman-THz spectroscopy of liquid water, which has been presented recently (Proc. Natl. Acad. Sci. USA 110, 20402 (2013)), directly probes the intermolecular degrees of freedom o…
Towards a microscopic description of the free-energy landscape of water
Diego Prada-Gracia, Roman Shevchuk, Peter Hamm +1
Free-energy landscape theory is often used to describe complex molecular systems. Here, a microscopic description of water structure and dynamics based on configuration-space-netwo…
Semiclassical and quantum polarons in crystaline acetanilide
Peter Hamm, G. P. Tsironis
Crystalline acetanilide is a an organic solid with peptide bond structure similar to that of proteins. Two states appear in the amide I spectral region having drastically different…