3 papers
q-bio.BM2026
Ligand-Conditioned Discrete Diffusion for Protein Sequence-Structure Co-Design
Chen Wei, Fanding Xu, Minghao Sun +5
Proteins perform their biological functions through three-dimensional structures encoded by amino acid sequences, and ligand-binding protein co-design requires models that generate…
q-bio.BM2025
RiboPO: Preference Optimization for Structure- and Stability-Aware RNA Design
Minghao Sun, Hanqun Cao, Zhou Zhang +10
Designing RNA sequences that reliably adopt specified three-dimensional structures while maintaining thermodynamic stability remains challenging for synthetic biology and therapeut…
cs.LG2025
From Supervision to Exploration: What Does Protein Language Model Learn During Reinforcement Learning?
Hanqun Cao, Hongrui Zhang, Junde Xu +12
Protein language models (PLMs) have advanced computational protein science through large-scale pretraining and scalable architectures. In parallel, reinforcement learning (RL) has…