3 papers
stat.ME2026
Addressing Confounding by Indication Through (Un)Measured Centre Characteristics in Learn-As-you-GO(LAGO) Trials
Minh Thu Bui, Christopher T. Longenecker, Ante Bing +4
The Learn-As-you-Go (LAGO) design is an adaptive clinical trial design allowing modifications to multicomponent intervention packages across stages. Centers participate in more tha…
stat.ME2026
Optimizing Complex Health Intervention Packages through the Learn-As-you-GO (LAGO) Design
Donna Spiegelman, Dong Roman Xu, Ante Bing +11
In the face of vast numbers of preventable deaths worldwide and gaping disparities in their distribution, we cannot afford to conduct null and inconclusive effectiveness and implem…
stat.ME2025
Learn-As-you-GO (LAGO) Trials: Optimizing Trials for Effectiveness and Power to Prevent Failed Trials
Ante Bing, Donna Spiegelman, Judith J. Lok
The Learn-As-you-GO (LAGO) design provides a rigorous framework for adapting the intervention package based on accumulating data while the trial is ongoing. This article improves t…