34 citations · 69 across the 11 of their papers we have counts for
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On the anti-quasi-steady-state conditions of enzyme kinetics
Justin Eilertsen, Santiago Schnell, Sebastian Walcher
Quasi-steady state reductions for the irreversible Michaelis--Menten reaction mechanism are of interest both from a theoretical and an experimental design perspective. A number of…
Hunting : The origin and validity of quasi-steady-state reductions in enzyme kinetics
Justin Eilertsen, Malgorzata Anna Tyczynska, Santiago Schnell
The estimation of the kinetic parameters requires the careful design of experiments under a constrained set of conditions. Many estimates reported in the literature incorporate pro…
On the validity of the stochastic quasi-steady-state approximation in open enzyme catalyzed reactions: Timescale separation or singular perturbation?
Justin Eilertsen, Santiago Schnell
The quasi-steady-state approximation is widely used to develop simplified deterministic or stochastic models of enzyme catalyzed reactions. In deterministic models, the quasi-stead…
On the quasi-steady-state approximation in an open Michaelis--Menten reaction mechanism
Justin Eilertsen, Marc R. Roussel, Santiago Schnell +1
The conditions for the validity of the standard quasi-steady-state approximation in the Michaelis--Menten mechanism in a closed reaction vessel have been well studied, but much les…
Stochastic enzyme kinetics and the quasi-steady-state reductions: Application of the slow scale linear noise approximation à la Fenichel
Justin Eilertsen, Kashvi Srivastava, Santiago Schnell
The linear noise approximation models the random fluctuations from the mean-field model of a chemical reaction that unfolds near the thermodynamic limit. Specifically, the fluctuat…