4 papers
Modeling tumor cell heterogeneity and plasticity in adaptive therapy
Rui Yue, Chenghang Li, Jinzhi Lei
Adaptive therapy (AT) is designed to postpone the emergence of drug resistance by exploiting evolutionary competition among tumor subclones. Most mathematical models of AT assume a…
Effects of multi-phase control mechanism on fibroblast dynamics: A segmented mathematical modeling approach
Shuqi Fan, Yuhang Zhang, Jinzhi Lei
Cell size is a fundamental determinant of cellular physiology, influencing processes such as growth, division, and function. In this study, we develop a segmented mathematical fram…
Quantitative analysis of cell size control mechanisms
Shuqi Fan, Jinzhi Lei
Cell size control is crucial for maintaining cellular function and homeostasis. In this study, we develop a first-order partial differential equation model to examine the effects o…
scRDiT: Generating single-cell RNA-seq data by diffusion transformers and accelerating sampling
Shengze Dong, Zhuorui Cui, Ding Liu +1
Motivation: Single-cell RNA sequencing (scRNA-seq) is a groundbreaking technology extensively utilized in biological research, facilitating the examination of gene expression at th…