2 papers
q-bio.QM2026
Multimodal reasoning for broadly neutralizing antibody discovery from label-free human B cell repertoires across virus families
Hantao Lou, Jianqing Zheng, Can Yue +21
Discovering broadly neutralizing antibodies (bnAbs) from human natural immune repertoires remains a fundamental challenge in immunology, hindered by: the extreme rarity of bnAb, in…
cs.CE2026
CaliPPer: quantifying, predicting and improving AI model performance for binding prediction
Jian-Qing Zheng, Hantao Lou, Zinan Yin +6
Binding prediction models accelerate therapeutic antibody and TCR discovery, but their performance on new datasets is unpredictable, often leading to low discovery rates. Density-r…