2 citations · 2 across the 6 of their papers we have counts for
3 papers · 1 filter
Biology-in-the-loop: Amortized Adaptive Hit Discovery in CRISPR Screens
Carl Edwards, Edward De Brouwer, Xiner Li +5
Many biological discovery problems require experiments to be selected sequentially under constrained budgets. CRISPR screening is a prominent example, as exhaustive perturbation te…
scCBGM: Interpretable Single-Cell Counterfactual Editing
Alma Andersson, Aya Abdelsalam Ismail, Edward De Brouwer +6
Understanding cellular phenotypes and how they respond to perturbations is critical for disease biology and therapeutic design. Single-cell RNA sequencing enables characterization…
Generate in Reconstruction Space, Match in Semantic Space: Transport Geometry for One-Step Generation
Hugues Van Assel, Edward De Brouwer, Saeed Saremi +2
Generative modeling and self-supervised representation learning (SSL) optimize structurally different objectives: generative training rewards distributional fidelity, while SSL rew…