3 papers
q-bio.CB2026
Optimisation of neoadjuvant pembrolizumab therapy for locally advanced MSI-H/dMMR colorectal cancer using data-driven delay integro-differential equations
Georgio Hawi, Peter S. Kim, Peter P. Lee
Colorectal cancer (CRC) poses a major public health challenge due to its increasing prevalence, particularly among younger populations. Microsatellite instability-high (MSI-H) CRC…
q-bio.QM2026
Sensitivity analysis-guided model reduction of a mathematical model of pembrolizumab therapy for de novo metastatic MSI-H/dMMR colorectal cancer
Georgio Hawi, Peter S. Kim, Peter P. Lee
Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide and the leading cause of cancer-related deaths in adults under 55, involving a complex interplay of bi…
q-bio.CB2026
Spatial dynamic modelling to understand how dendritic cell clustering affects T cell activation
Domenic P. J. Germano, Federico Frascoli, Robyn P. Araujo +2
The coordination of the immune system and its components is essential for the body to maintain a healthy status. Recent clinical studies show that breast cancer patients with high…