6 papers
Global geometry of the genotype-phenotype map illuminates a trade-off between penetrance and mutational adaptability
Yutaro Ikeda, Kunihiko Kaneko, Tetsuhiro S. Hatakeyama
Evolution in changing environments requires both reliable expression of the currently favored phenotype, as quantified by penetrance, and the capacity to reach alternative phenotyp…
Self-Organized Bioelectricity via Collective Pump Alignment: Toward a Physical Origin of Chemiosmosis
Ryosuke Nishide, Kunihiko Kaneko
Directional ion transport across membranes maintains living systems in nonequilibrium, which underlies chemiosmotic energy conversion. However, the physical origin of collectively…
Delayed control driven oscillations in plant roots
Riz Fernando Noronha, Kunihiko Kaneko, Koichi Fujimoto
Arabidopsis roots show oscillatory growth patterns on homogeneous agar surfaces, whereas other plants, such as maize, do not. Although several explanations have been proposed, a si…
Noise-Driven Differentiation via Gene Frustration and Epigenetic Fixation
Davey Plugers, Kunihiko Kaneko
Gene expression in cells is stochastic, yet differentiation can display reproducible timing and stable fate commitment. We develop an analytical theory for a previously identified…
Enzyme as Maxwell's Demon: Steady-state Deviation from Chemical Equilibrium by Enhanced Enzyme Diffusion
Shunsuke Ichii, Tetsuhiro S. Hatakeyama, Kunihiko Kaneko
Enhanced enzyme diffusion (EED), in which the diffusion coefficient of an enzyme transiently increases during catalysis, has been extensively reported experimentally. We numericall…
Dimensional reduction and adaptation-development-evolution relation in evolved biological systems
Kunihiko Kaneko
Life systems are complex and hierarchical, with diverse components at different scales, yet they sustain themselves, grow, and evolve over time. How can a theory of such complex bi…