3 papers
cs.LG2026
FLAG: Foundation model representation with Latent diffusion Alignment via Graph for spatial gene expression prediction
Qi Si, Penglei Wang, Yushuai Wu +5
Predicting spatial gene expression from routine H\&E enables large-scale molecular profiling, yet current models treat this as isolated pointwise tasks, thereby overlooking essenti…
q-bio.GN2025
ChromFound: Towards A Universal Foundation Model for Single-Cell Chromatin Accessibility Data
Yifeng Jiao, Yuchen Liu, Yu Zhang +9
The advent of single-cell Assay for Transposase-Accessible Chromatin using sequencing (scATAC-seq) offers an innovative perspective for deciphering regulatory mechanisms by assembl…
q-bio.QM2025
PAST: A multimodal single-cell foundation model for histopathology and spatial transcriptomics in cancer
Changchun Yang, Haoyang Li, Yushuai Wu +8
While pathology foundation models have transformed cancer image analysis, they often lack integration with molecular data at single-cell resolution, limiting their utility for prec…