2 citations · 2 across the 2 of their papers we have counts for
3 papers
MechAInistic: An LLM-guided Multi-Agent System for Reasoning over Genome-Scale Constraint-Based Metabolic Models
Josh Loecker, Narayna Puraja, William Bryan +3
Constraint-based metabolic modeling is a powerful way to study the mechanistic basis of cellular states and disease, but its effective use demands substantial computational experti…
COMO: A Pipeline for Multi-Omics Data Integration in Metabolic Modeling and Drug Discovery
Brandt Bessell, Josh Loecker, Zhongyuan Zhao +5
Identifying potential drug targets using metabolic modeling requires integrating multiple modeling methods and heterogenous biological datasets, which can be challenging without so…
Systems Perturbation Analysis of a Large Scale Signal Transduction Model Reveals Potentially Influential Candidates for Cancer Therapeutics
Bhanwar Lal Puniya, Laura Allen, Colleen Hochfelder +2
Dysregulation in signal transduction pathways can lead to a variety of complex disorders, including cancer. Computational approaches such as network analysis are important tools to…