2 papers
stat.ME2026
A flexible framework for treatment effect inference in longitudinal clinical studies with skewed outcomes
Kazushi Maruo, Ryota Ishii, Yusuke Yamaguchi +3
Longitudinal continuous outcomes in clinical trials are commonly analyzed using mixed models for repeated measures (MMRM) under normality assumptions. However, many clinical outcom…
stat.ME2026
Modification and extension of the Bayesian clinical trial design using external data for single-arm and hybrid-controlled trials
Wataru Murasaki, Tomohiro Ohigashi, Ryota Ishii +2
Limited patient availability complicates sample size determination in pediatric clinical trials. Although Bayesian methods incorporating external data offer a solution, rigorously…