5 papers
Single-Pass Decision Scores Enable Rapid Classification with Adjustable Thresholds in Medical Multimodal Large Language Models
Patrick Wienholt, Frederik Hauke, Christiane Kuhl +3
Multimodal large language models (MLLMs) answer binary clinical questions with a yes or no token, leaving the decision threshold implicit and fixed. We derive a continuous score fr…
Foundation-model-guided radiogenomic discovery linking cancer genomes to cancer scans
Frederik Hauke, Jeremias Krause, Patrick Wienholt +6
The function of many genes is still unknown, and conventional driver-discovery methods, which rely on how frequently a gene is mutated, cannot assess genes that are only rarely aff…
Bayesian uncertainty estimation improves clinical decision making in medical AI agents
Frederik Hauke, Patrick Wienholt, Christiane Kuhl +4
Machine learning models for medical image analysis typically lack a reliable measure of confidence, limiting their use in ambiguous or atypical cases. Here we show that Monte Carlo…
From Clinical Intent to Clinical Model: Autonomous Coding-Agents for Clinician-driven AI Development
Zihao Zhao, Frederik Hauke, Juliana De Castilhos +4
Developing AI models that are useful in clinical practice, requires efficient collaboration between clinicians and AI developers. This poses a practical challenge: clinicians must…
Can Agents Distinguish Visually Hard-to-Separate Diseases in a Zero-Shot Setting? A Pilot Study
Zihao Zhao, Frederik Hauke, Juliana De Castilhos +2
The rapid progress of multimodal large language models (MLLMs) has led to increasing interest in agent-based systems. While most prior work in medical imaging concentrates on autom…