3 citations · 6 across the 6 of their papers we have counts for
3 papers · 1 filter
Estimands and estimation in trials with time trends
Marta Bofill Roig, Ekkehard Glimm, Kelly Van Lancker +1
In platform trials, model-based approaches typically estimate treatment effects conditional on calendar time. However, scientific and regulatory interest often lies in treatment ef…
On the use of G-computation in small randomized controlled trials with many covariates
Muluneh Alene, Kelly Van Lancker, Stijn Vansteelandt
In contemporary randomized controlled trials (RCTs), the number of patients is often small relative to the number of baseline covariates collected. In such settings, maximum likeli…
Towards Best Practices for Covariate Adjustment in Regulatory Trials: From Fixed to Data-Adaptive Approaches
Laura B. Balzer, Lei Nie, Issa J. Dahabreh +15
While randomization justifies the use of unadjusted effect estimators in randomized trials, there is growing interest in covariate adjustment to improve precision. Adjusting for ba…