2 papers
stat.ME2026
Testing for subgroup treatment effect consistency in the Cox model
Lukas Koletzko, Holger Dette, Björn Bornkamp +2
An overall treatment effect in a clinical trial may inadequately represent particular patient subgroups, creating uncertainty about whether a population-level efficacy conclusion c…
math.ST2024
Testing for similarity of dose response in multi-regional clinical trials
Holger Dette, Lukas Koletzko, Frank Bretz
This paper addresses the problem of deciding whether the dose response relationships between subgroups and the full population in a multi-regional trial are similar to each other.…