4 papers
Kinetic Proofreading Activation Times Beyond the Weibull Limit
Thomas Mourier, Cameron Hopkinson, Kenny Wong
T cells can detect a few foreign peptide-major histocompatibility complexes (pMHCs) among a far larger number of self pMHCs. Kinetic proofreading explains this discrimination: a re…
Approximate Analytical Protein Distributions for the Three-stage Model of Stochastic Gene Expression
Kenny Wong, Thomas Mourier, Sho Inaba +2
Gene expression is an intrinsically stochastic process that generates phenotypic heterogeneity within genetically identical cell populations. While the exact statistical moments of…
Post-transcriptional Regulation of Stochastic Gene Expression Conditioned on Large Deviations
Kenny Wong, Thomas Mourier, Cameron Hopkinson
Gene expression is a stochastic process that gives rise to large fluctuations in protein levels leading to phenotypic heterogeneity in clonal cell populations; post-transcriptional…
Analyzing Post-transcriptional Regulation in Stochastic Gene Expression Models Using Partitioned Poisson Arrivals
Kenny Wong, Argenis Arriojas, Sho Inaba +3
Gene expression is a stochastic process that allows for fluctuations in protein levels that can give rise to phenotypic heterogeneity within a population of genetically identical c…