2 papers
q-bio.BM2026
Is Retrieval All You Need? Assessment and Emergence of Novelty in Protein Structure Generation
Tongyue Xu, Yijie Zhang, Mutian He +4
Protein backbone generation models are often credited with exploring novel fold space based solely on low full-chain similarity to known proteins, yet this cannot distinguish a gen…
cs.CE2026
LineageFlow: Flow Matching for High-Fidelity Family-Aware Protein Sequence Generation
Langzhang Liang, Ming Yang, Yi Feng +6
Protein sequence generation for engineering requires samples that are biophysically plausible and, when targeting a family/domain, remain recognizable members while exploring withi…