5 papers
DNA Methylation Profiling in Melanoma: From Lesion Classification to Therapeutic Stratification
Jana T. Winterstein, Lukas Heinlein, Günter Raddatz +34
DNA methylation provides a stable record of cellular identity, capturing epigenetic programs that distinguish specialized cell states despite a shared genome. Because malignant tra…
Superhuman performance in urology board questions by an explainable large language model enabled for context integration of the European Association of Urology guidelines: the UroBot study
Martin J. Hetz, Nicolas Carl, Sarah Haggenmüller +4
Large Language Models (LLMs) are revolutionizing medical Question-Answering (medQA) through extensive use of medical literature. However, their performance is often hampered by out…
Advancing dermatological diagnosis: Development of a hyperspectral dermatoscope for enhanced skin imaging
Martin J. Hetz, Carina Nogueira Garcia, Sarah Haggenmüller +1
Clinical dermatology necessitates precision and innovation for efficient diagnosis and treatment of various skin conditions. This paper introduces the development of a cutting-edge…
Clinical Melanoma Diagnosis with Artificial Intelligence: Insights from a Prospective Multicenter Study
Lukas Heinlein, Roman C. Maron, Achim Hekler +27
Early detection of melanoma, a potentially lethal type of skin cancer with high prevalence worldwide, improves patient prognosis. In retrospective studies, artificial intelligence…
Evaluating Deep Learning-based Melanoma Classification using Immunohistochemistry and Routine Histology: A Three Center Study
Christoph Wies, Lucas Schneider, Sarah Haggenmueller +6
Pathologists routinely use immunohistochemical (IHC)-stained tissue slides against MelanA in addition to hematoxylin and eosin (H&E)-stained slides to improve their accuracy in dia…